The most prominent characteristic of seaweed is Paucity of basic information describing the activity and function Its usefulness as a biomarker, and the development of a DNA markerīased on the genomic sequence of the laver Pyropia species Seaweed, including the partial creation of a seaweed proteinĭatabase, identification of a seaweed protein that changesĪccording to stress and environment, proteomic investigations on Have progressed our understanding of the bioactive components in There has been limited investigation of seaweed proteins and Solvent extracts, rather than mono-constituent substances, and The majority of studies on seaweed bioactivity have investigated With anticancer, antiviral and anticoagulant effects ( 1- 5). Studies have reported that seaweed has various bioactive substances Seaweed, including laver, is a standard foodĬonsumed in Asian countries, including Korea and Japan. Therefore, from the investigations of P. yezoensis, several candidate peptides were identified with promising antioxidant and, potentially, anti‑aging properties. Overall, these results suggested that Nrf2-SOD pathways may be involved in the PBP2‑mediated antioxidant effects. Furthermore, phosphorylated nuclear factor erythroid‑derived 2‑like 2 (Nrf2) was elevated by PBP2 treatment. In HepG2 cells, treatment with PBP2 reduced hydrogen peroxide‑mediated oxidative stress and restored the expression of superoxide dismutase (SOD). In addition, PBP 1‑2 and 7‑9 peptides from PE were synthesized and showed antioxidant activities in HepG2 cells.
Pbp3 dtt Pc#
The existence of PBPs of each type, PE, PC and APC, was established in P. yezoensis and all were analyzed. In the present study, PBPs reported previously to have antioxidant activities in P. yezoensis were identified and, based on these data, several peptides were synthesized (PBP 1‑13) and their inhibition of ROS generation was examined. There are three types of pigment bound proteins, known as phycobiliproteins (PBPs): Phycoerythrin (PE), phycocyanin (PC) and allophycocyanin (APC). Phycobilin, specific to red algae, covalently binds with water‑soluble proteins. The objective of the present study was to identify peptides, based on active components of the red algae seaweed Pyropia yezoensis, able to inhibit the generation of reactive oxygen species (ROS), which is associated with aging and oxidative activities.
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